Ugene

Unipro UGENE is a bioinformatics application that brings together tools for working with biological data. The project describes it as free and open-source software for macOS, Windows, and Linux; the Homebrew cask installs the macOS application.

• UGENE is presented as an integrated bioinformatics toolkit.
• The project publishes research papers describing applications that include variant calling, RNA-seq and ChIP-seq analyses, and metagenomics pipelines.
• The project provides documentation, instructional videos, a public forum, and a bug-tracking system as support resources.

Install the macOS app with brew install --cask unipro-ugene. The cask requires Rosetta, and its download is a macOS x86-64 disk image. After installation, open Unipro UGENE.app from Applications. The published macOS package therefore requires Rosetta on systems where it is needed to run the x86-64 app.

Sources: UGENE official website; Homebrew cask